![]() ![]() ![]() Improved understanding of how alterations of ceramide in particular subcellular locations impact downstream functions, the functional significance of the individual ceramide species, and how ceramide metabolism is regulated in response to individual stress stimuli, should permit more focused investigation into the molecular action of ceramide. ![]() Ceramide has been suggested to play a number of regulatory roles in cells. Much of the current literature on the role of ceramide in cell regulation involves the measurement of whole cell ceramides. Many targets of ceramide have been identified in vivo that could indirectly alter mitochondrial function and lead to the initiation of apoptosis. There are two main pathways for apoptosis, namely the extrinsic receptor-mediated pathway and an intrinsic mitochondrial pathway. Following this, it presents an overview of apoptosis. It begins with an explanation of ceramide metabolism, which involves several sphingolipids with important and distinct cellular functions. This chapter presents an overview of the role of ceramide in cellular regulation, with a focus on its role in apoptosis. Ceramides and other sphingolipids play important roles in coordinating cellular responses to extracellular stimuli and to stress. Obeid, in Handbook of Cell Signaling (Second Edition), 2010 Publisher SummaryĬeramides are a family of lipid molecules, composed of sphingosine and a fatty acid, and are found in high concentrations within the cell membrane of cells. ![]()
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